Research Associate I/II - Transgenic Colony Management, Research Operations

Allen Institute - Seattle, WA (30+ days ago)

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The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

The Research Associate I/II is responsible for executing a variety of laboratory tasks and/or experiments in a high-throughput mouse breeding colony and animal care environment (vivarium) following Standard Operating Procedures (SOPs) and work instructions (WI). Good judgment and problem-solving skills are required for forecasting breeding colony needs, recognizing process deviations, participating in quality control (QC) and troubleshooting efforts, and operation of laboratory instrumentation.

The Research Associate I/II is expected to comply with regulatory requirements, and to work efficiently in a team science environment. Excellent manual dexterity, attention to detail and the willingness to work in a deadline-driven atmosphere is mandatory. Upon completion of training, the Research Associate I/II is expected to work with little or no supervision on procedural tasks involving handling and care of mice and may be expected to train others in detailed protocols and procedures.

Essential Functions

Perform daily colony management and maintenance tasks including tail biopsy collection and paw tattooing of mice, weaning of new litters, etc.
Maintenance of health and behavior performance records, including genotyping data
Perform colony management duties including planning and execution of sophisticated breeding strategies
Attend internal scientific project team meetings and interact with scientists, principal investigators and the veterinarian to meet all transgenic colony needs
Training of new or existing TCM staff, commensurate with experience
Phenotyping of new transgenic mouse lines
Composition of, and adherence to, work instructions, SOPs and training documents
Follow good laboratory practices, and regulatory requirements in accordance with the “NIH Guide for the Care and Use of Laboratory Animals”
Performance of non-SOP procedures under limited supervision and/or guidance
Performance of tasks with limited supervision on occasional weekends and/or holidays
Maintain accurate laboratory documentation and reporting using established methods
Work with Supervisor to adhere to appropriate management and prioritization of tasks and time, including daily and weekly scheduling

Required Education and Experience

Bachelor’s degree (B.S. or B.A.) in a life science discipline
RA1: 0-2 years of related work experience, with hands-on animal husbandry experience required
RA2: 2-4 years of experience, with hands-on rodent husbandry experience required
Basic knowledge of mouse genetics and anatomy
Basic level ability with MS Office, MS Access and ability to learn other custom software systems (LabTracks, LIMS)

Preferred Education and Experience

>1 year direct experience with animal handling in a mouse breeding colony setting
Experience working in a research environment
Knowledge of molecular biology (e.g. PCR, genotyping, mouse transgenesis) preferred
Administration of compounds to mice (i.v., i.p., s.c., p.o., i.m.)
Ability to work independently and within a collaborative, multi-disciplinary environment
Positive attitude, self-starter, demonstrated attention to detail, and ability to trouble-shoot
Outstanding oral and written communication skills
Proficiency with Lab Tracks strongly preferred

Work Environment

Exposure and handling of laboratory animals required
Laboratory atmosphere - possible exposure to chemical, biological or other hazardous substances
Possible exposure to BioSafety Level 2 organisms, such as recombinant viruses

Physical Demands

Ability to lift and move 40 lbs on a regular basis and sustained physical activities such as bending, balancing, stooping, reaching, and remain standing for long periods of time
Duties include motions that are repetitive tasks

Position Type/Expected Hours of Work

This position is essential to the care of animals and expected to report to work daily, even in the event of inclement weather conditions
Work on-call, weekend, or holiday shifts as needed or as assigned

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.